Антигипоксическое и нейропротекторное действие N-арахидоноилдофамина при моделировании острой гипоксии in vivo и in vintro
Ретроградная модуляция синаптической передачи эндоканнабиноидами. Культивирование первичных диссоциированных клеток гиппокампа. Влияние N-арахидоноилдофамина на спонтанную биоэлектрическую активность культивируемых клеток гиппокампа при гипоксии.
Рубрика | Биология и естествознание |
Вид | диссертация |
Язык | русский |
Дата добавления | 21.06.2015 |
Размер файла | 1,4 M |
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115. Lara-Celador I, Goсi-de-Cerio F, Alvarez A, Hilario E. Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic- ischemic brain injury // Neural. Regen. Res. 2013. Vol. 8, Is. 8. P. 731-744.
116. Leker RR, Gai N, et al. Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210 // Stroke. 2003. Vol. 34. №8. Р. 2000- 2006.
117. Lenz R.A., Wagner J.J., Alger B.E. N- and L-type calcium channel involvement in depolarization-induced suppression of inhibition in rat hippocampal CA1 cells // J. Physiol. 1998. Vol. 512. P. 61-73.
118. Li Y., Zhou W., Li X., Zeng S., Liu M., Luo Q. Characterization of synchronized bursts in cultured hippocampal neuronal networks with learning training on microelectrode arrays // Biosens Bioelectron. 2007. Vol. 22, №12. P. 2976-2982.
119. Liu J., Wang L., Harvey-White J. et al. A biosynthetic pathway for anandamide // Proc. Natl. Acad. Sci. U S A. 2006. V. 103. P. 13345-13350.
120. Lozovaya N, Yatsenko N, Beketov A, Tsintsadze T, Burnashev N. Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids // J. Neurosci. 2005. Vol. 25. Is.33. P. 7499-7506.
121. Maccarrone M, Bari M, Lorenzon T, Bisogno T, Di Marzo V, Finazzi-Agrт A. Anandamide uptake by human endothelial cells and its regulation by nitric oxide // J. Biol. Chem. 2000. Vol.275. Is. 18. P. 13484-13492.
122. Mackie K. Distribution of cannabinoid receptors in the central and peripheral nervous system // Handbook of experimental pharmacology. 2005. Vol. 168. P. 299-325.
123. Mackie K., Lai Y., Westenbroek R., Mitchell R. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor // J. Neurosci. 1995. Vol.15. Is.10. P. 6552-6561.
124. Madhavan R., Chao Z.C., Potter S.M. Spontaneous bursts are better indicators of tetanus-induced plasticity than responses to probe stimuli // Proceeding of Second International IEEE EMBS Conference on Neural Engineering. 2006. P. 5-8.
125. Madhavan R, Chao ZC, Potter SM. Plasticity of recurring spatiotemporal activity patterns in cortical networks // Phys Biol. 2007. Vol.4, Is.3. p. 181-93.
126. Maresz K., Carrier E.J., Ponomarev E.D., Hillard C.J., Dittel B.N. Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli // J. Neurochem. 2005. Vol.95. Is.2. P. 437-445.
127. Maresz K., Pryce G, et al. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB(1) on neurons and CB(2) on autoreactive T cells // Nat. Med. 2007. Vol.13. №4. 492-497.
128. Marinelli S., Di Marzo V., Florenzano F., et al. N-Arachidonoyl-Dopamine Tunes Synaptic Transmission onto Dopaminergic Neurons by Activating both Cannabinoid and Vanilloid Receptors // Neuropsychopharmacology. 2007. Vol. 32, Р. 298-308.
129. Marsicano G., Moosmann B., Hermann H. et al. Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1 // J. Neurochem. 2002. Vol. 80, №3. P. 448-456.
130. Massi P., Valenti M., Bolognini D., Parolaro D. Expression and Function of the Endocannabinoid System in Glial Cells // Current Pharmaceutical Design. 2008. Vol. 14. № 23. P. 2289-2298.
131. McCollum L., Howlett A.C., Mukhopadhyay S. Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells // J. Pharmacol. Exp. Ther. 2007. Vol. 321. Is.3. P. 930-937.
132. McFarland M.J., Rakhshan F.R., Wilson J.L., Barker E.L. Endocytic and cellular trafficking processes involved with uptake and metabolism of anandamide // Exp. Biol. (Abstract). 2004. Vol. 397. P. 8.
133. Mechoulam R., Ben-Shabat S., Hanus L. et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors // Biochem. Pharmacol. 1995. Vol. 50. P. 83-90.
134. Mechoulam R., Panikashvili D and Shohami E. Cannabinoids and brain injury: therapeutic implications // TRENDS in Molecular Medicine. 2002.Vol.8, №2. P. 58 -61.
135. Mechoulam R., Shohami, E., 2007. Endocannabinoids and traumatic brain injury // Mol. Neurobiol. Vol. 36. Р. 68-74.
136. Mehta A., Prabhakar M., Kumar P., Deshmukh R., Sharma P.L. Excitotoxicity: bridge to v arious triggers in neurodegenerative disorders // Eur. J. Pharmacol. 2013. Vol. 698, №1-3. P. 6-18.
137. Moesgaard B., Hansen H.H., Hansen S.L., Hansen S.H., Petersen G., Hansen H.S. Brain levels of N-acylethanolamine phospholipids in mice during pentylenetetrazol-induced seizure // Lipids. 2003. Vol. 38. Is.4. P. 387-390.
138. Morena M, Campolongo P. The endocannabinoid system: an emotional buffer in the modulation of memory function // Neurobiol Learn Mem. 2014. Vol. 112. P. 30-43.
139. Morgan N.H., Stanford I.M., Woodhall G.L. Functional CB2 type cannabinoid receptors at CNS synapses // Neuropharmacology. 2009. Vol. 57. P. 356-368.
140. Morris R.G.M. Development of a water-maze procedure for studing spatial learning in the rat // Neurosci. Meth. 1984. №11. Р. 47-60.
141. Morris R.G.M., Garrud P., O'Keefe J. Place navigation impaired in rats with hippocampal lesions // Nature. 1982. №297. Р. 681-683.
142. Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids // Nature. 1993. Vol. 365. P. 61-65.
143. Murikinati S., Jutler E., Keinert T., Ridder D., Muhammad S., Waibler Z., Ledent C., Zimmer A., Kalinke U., Schwaninger M, Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment // The FASEB Journal. 2010. Vol. 24. Р. 788-798.
144. Muthian S, Rademacher DJ, et al. Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia // Neuroscience. 2004. Vol.129, №3. Р. 743-750.
145. Nagakura A., Takagi N., Takeo S. Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats // Neurosci. 2002. Vol. 113, № 3. P. 519-528.
146. Nagayama T., Sinor A.D., et al. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures // J. Neurosci. 1999. Vol 19, №8. Р. 2987-2995.
147. Netto C.A. et al Effects of fetal hippocampal field grafts on ischemic- induced deficits in spatial navigation in the water maze // Neurosci. 1993. Vol. 54, № 1. P. 69-92.
148. Nimmerjahn A, Kirchhoff F, Kerr JN, Heimchen F. Sulforphodamine 101 as a specific marker of astroglia in the neocortex in vivo // Nat. methods. 2004. Vol.1. P. 31-37.
149. Nunez L., Sanchez A., Fonteris R.I., Garcia-Sancho J. Mechanisms for synchronous calcium oscillations in cultured rat cerebellar neurons // Eur.J. Neurosci. 1996. Vol.8. P. 192-201.
150. Nъсez L, Senovilla L, Sanz-Blasco S, Chamero P, Alonso MT, Villalobos C, Garcнa-Sancho J. Bioluminescence imaging of mitochondrial Ca2+ dynamics in soma and neurites of individual adult mouse sympathetic neurons // J. Physiol. 2007. Vol. 580. P. 385-395.
151. Ohno-Shosaku T., Tsubokawa H., Mizushima I., Yoneda N., Zimmer A., Kano M. Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses // J Neurosci. 2002. Vol. 22. Is.10. P. 3864-3872.
152. Okamoto Y., Morishita J., Tsuboi K. et al. Molecular characterization of a phospholipase D generating anandamide and its congeners // J. Biol. Chem. 2004. Vol. 279. P. 5298-5305.
153. O'Sullivan S.E., Kendall D.A., Randall M.D. Characterisation of the vasorelaxant properties of the novel endocannabinoid N-arachidonoyl-dopamine (NADA) // Br. J. Pharmacol. 2004. Vol. 141. P. 803-812.
154. Palazuelos J., Aguado T., Egia A. et al. Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation // FASEB J. 2006. Vol. 20. P. 2405-2407.
155. Panikashvili D, Simeonidou C, Ben-Shabat S, et al. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury // Nature. 2001. Vol. 413. р. 527-531.
156. Panikashvili D., Mecholam R. et al. CB1 cannabinoid receptors are involved in neuroprotection via NF-кB inhibition // J. Cereb. Blood Flow Metab. 2005. Vol. 25. Р. 477-484.
157. Panikashvili D., Shein N.A., Mechoulam R., Trembovler V., Kohen R., Alexandrovich A., Shohami E. The endocannabinoid 2-AG protects the blood- brain barrier after closed head injury and inhibits mRNA expression of proin?ammatory cytokines // Neurobiol. Dis.2006. Vol. 22. P. 257-264.
158. Paredes M., Etzler J.C., Watts L.T., Zheng W., Lechleiter J.D. Chemical calcium indicators // Methods. 2008. Vol.46. P. 143-151.
159. Parmentier-Batteur S, Jin K, et al. Increased severity of stroke in CB1 cannabinoid receptor knock-out mice // J. Neurosci. 2002. Vol. 22, №22. Р. 9771- 9775.
160. Pazos MR, Mohammed N, Lafuente H, Santos M, Martнnez-Pinilla E, Moreno E, Valdizan E, Romero J, Pazos A, Franco R, Hillard CJ, Alvarez FJ, Martнnez-Orgado J. Mechanisms of cannabidiol neuroprotection in hypoxic- ischemic newborn pigs: role of 5HT(1A) and CB2 receptors // Neuropharmacology. 2013. Vol. 71. P. 282-291.
161. Patel N.A., Moldow R.L., Patel J.A., Wu G., Chang S.L. Arachidonylethanolamide (AEA) activation of FOS proto-oncogene protein immunoreactivity in the rat brain // Brain Res. 1998. Vol.797. Is.2. P. 225-233.
162. Pertwee R.G. Cannabinoid pharmacology: the first 66 years // British Journal of Pharmacology. 2006. Vol. 147. P. S163-S171.
163. Pertwee, R.G., Howlett, A.C., Abood, M.E et al. // International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB and CB. Pharmacol. Rev. 2010. Vol. 62. Р. 588-631.
164. Pimashkin A., Kastalskiy I., Simonov A., Koryagina E., Mukhina I., Kazantsev V. Spiking signatures of spontaneous activity bursts in hippocampal cultures // Frontiers in Computational Neuroscience. 2011. 5(46) doi: 10.3389/fncom.2011.00046.
165. Pine J. Recording action potentials from cultured neurons with extracellular microcircuit electrodes // J. Neurosci. Methods. 1980. Vol. 2, №1. P. 19-31.
166. Price T.J., Patwardhan A., Akopian A.N., Hargreaves K.M., Flores C.M. Modulation of trigeminal sensory neuron activity by the dual cannabinoid- vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2- chloroethylamide // Br. J. Pharmacol. 2006. Vol 141, №7. P. 1118-1130.
167. Ralevic V, Kendall D.A., Randall M.D., Smart D. Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function // Life Sci. 2002. Vol 71, №22. Р. 2577- 2594.
168. Riedel G, Davies S.N. Cannabinoid function in learning, memory and plasticity // / In: Cannabinoids. Handbook of Experimental Pharmacology. 2005. Vol. 168. P. 445-477.
169. Rodriguez J.J., Mackie K., Pickel V.M. Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus // Neurosci. 2001. V. 21.P. 823-833.
170. Ryberg E., Larsson N., Sjцgren S., Hjorth S., Hermansson N.O., Leonova J., Elebring T., Nilsson K., Drmota T., Greasley P.J. The orphan receptor GPR55 is a novel cannabinoid receptor // British Journal of Pharmacology. 2007. Vol. 152, №7. Р. 1092-1101.
171. Sagar D.R., Smith P.A., Millns P.J., Smart D., Kendall D.A., Chapman V. TRPV1 and CB(1) receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent ibre and spinal cord neuronal responses in the rat // Eur. J. Neurosci. 2004. Vol.20. Р. 175-184.
172. Sagie S, Eliasi Y, Livneh I, Bart Y, Monovich E. Short-and long-term effects of cannabinoids on memory, cognition and mental illness // Harefuah. 2013. vol. 152. Is. 12. P. 737-741.
173. Sбnchez-Blбzquez P., Rodrнguez-Muсoz M., Garzуn J. The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia // Front Pharmacol. 2014. Vol.4. Is. 169. doi: 10.3389/fphar.2013.00169.
174. Sapirstein A. and Bonventre J. V. Phospholipases A2 in ischemic and toxic brain injury // Neurochem. Res. 2000. Vol. 25. P. 745-753.
175. Sasamura T, Kuraishi Y. Peripheral and central actions of capsaicin and VR1 receptor // Jpn. J. Pharmacol. 1999. Vol. 80. Is.4. P. 275-80.
176. Schдbitz W.R., Giuffrida A., Berger C., Aschoff A., Schwaninger M., Schwab S., Piomelli D. Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study // Stroke. 2002. Vol. 33. P. 2112-2114.
177. Schmid P.C., Reddy P.V., Natarajan V., Schmid H.H. Metabolism of N- acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type // J. Biol. Chem. 1983. Vol. 258. P. 9302-9306.
178. Schomacher M., Mьller H. D., Sommer C. et al. Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia // Brain Research. 2008. Vol. 1240. P. 213-220.
179. Shen, M., Thayer, S.A. Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity // Mol. Pharmacol. 1998. Vol. 54. P. 459-462.
180. Shouman B, Fontaine RH, et al. Endocannabinoids potently protect the newborn brain against AMPAkainate receptor-mediated excitotoxic damage // Br. J. Pharmacol. 2006. Vol. 148, №4. Р. 442-451.
181. Silva A.J., Ciese K.p., Fedorov N.B., Frankland P.W., Kogan J.H. Molecular, cellular, and neuroanatomical substrates of place learning // Neurobiol. Learn. 1998. № 70. Р. 44-61.
182. Sinor A.D., Irvin, S.M., Greenberg, D.A. Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats // Neurosci. Lett. 2000. Vol. 278. P. 157-160.
183. Stelmashook E.V., Lozier E.R., Goryacheva E.S., Mergenthaler P., Novikova S.V., Zorov D.B. and Isaev N.K. Glutamine-mediated protection from neuronal cell death depends on mitochondrial activity // Neurosci. Lett. 2010. Vol. 482 (2). Р. 151-155.
184. Sugiura T. Biosynthesis of Anandamide and 2-Arachidonoylglycerol
/Cannabinoides and the brain. 2008. Р. 15-30.
185. Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, Yamashita A, Waku K. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain // Biochem Biophys Res Commun. 1995. Vol. 215(1). P. 89-97.
186. Sugiura T., Kobayashi Y., Oka S., Waku K. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance // Prostaglandins Leukot Essent Fatty Acids. 2002. Vol.66. P. 173- 192.
187. Sun Y.X., Tsuboi K., Zhao L.Y. et al. Involvement of N-acylethanolamine- hydrolyzing acid amidase in the degradation of anandamide and other Nacylethanolamines in macrophages // Biochim. Biophys. Acta. 2005. Vol. 1736. P. 211-220.
188. Szabo B. Pharmacology of cannabinoid receptors // Biotrend reviews. 2008.- №2. P. 1-13.
189. Szabo B., Dцrner L., Pfreundtner C., Nцrenberg W., Starke K. Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum // Neuroscience. 1998. Vol. 85, № 2. P. 395-403.
190. Szabo B., Schlicker E. Effects of Cannabinoids on Neurotransmission // In: Cannabinoids. Handbook of Experimental Pharmacology. 2005. Vol. 168. P. 327- 365.
191. Szabo B., Wallmichrath I., Mathonia P., Pfreundtner C. Cannabinoids inhibit excitatory neurotransmission in the substantia nigra pars reticulate // Neuroscience. 2000. Vol. 97, №1. P. 89-97.
192. Szallasi A., Cortright D.N., Blum C.A., Eid S.R. The vanilloid receptor TRPV1:10 years from channel cloning to antagonist proof-of-concept // Nat. Rev. Drug Discov. 2007. Vol.6. Р. 357-372.
193. Takahashi N., Sasaki T., Usami A., Matsuki N., Ikegaya Y. Watching neuronal circuit dynamics through functional multineuron calcium imaging (fMCI). // Neuroscience research. 2007. Vol. 58, № 3. P. 219-225.
194. Tan H, Ahmad T, Loureiro M, Zunder J, Laviolette SR. The role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia // Front Psychiatry. 2014. Vol. 5. Is. 73. doi: 10.3389/fpsyt.2014.00073.
195. Tanaka K. et al. Chronic cerebral hypoperfusion disrupts discriminative behavior in acquired-learning rats // J. Neurosci. Methods. 1998. Vol. 84, № 1-2. P. 63-68.
196. Ternianov A., Pйrez-Ortiz J.M., Solesio M.E., Garcнa-Gutiйrrez M.S., Ortega-Бlvaro A., Navarrete F., Leiva C., Galindo M.F., Manzanares J. Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine // Neurobiol Aging. 2012. Vol. 33, № 2. P.421-425.
197. Thurman, D.J., Alverson, C., Dunn, K.A., Guerrero, J., Sniezek, J.E., // Traumatic brain injury in the United States: a public health perspective. J. Head Trauma Rehabil. 1999. Vol.14. Р. 602-615.
198. Twitchell W., Brown S., Mackie K. Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons // J. Neurophysiol. 1997. Vol. 78. Is.1. P.43-50.
199. Van Der Stelt M., Di Marzo V. Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels // Eur J Biochem. 2004. Vol. 27. P.1827-1834.
200. Van der Stelt M., van Kuik J.A., Bari M. et al. Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase
// J. Med. Chem. 2002. Vol. 45. P. 3709-3720.
201. Van der Stelt M., Veldhuis W.B. et al. Neuroprotection by Delta9- tetrahydrocannabinol, the main active compound in marijuana, against ouabain- induced in vivo excitotoxicity // J. Neurosci. 2001. Vol 21, №17. Р. 6475-6479.
202. Virley D. et al. Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field // Brain. 1999. Vol. 122, №. 12. P. 2321-2335.
203. Wagenaar D.A., Pine J., Potter S. M. An extremely rich repertoire of bursting patterns during the development of cortical cultures // BMC Neurosci. 2006. Feb 7. Art. no. 11.
204. Walker J.M., Krey J.F., Chen J.S., Vefring E., Jahnsen J.A., Bradshaw H., Huang S.M. Targeted lipidomics: fatty acid amides and pain modulation // Prostaglandins Other Lipid Mediat. 2005. Vol. 77. Is. 1-4. P.35-45.
205. Wang K. K. Calpain and caspase: can you tell the difference? // Trends. Neurosci. 2000. Vol. 23. P. 20-26.
206. Westlake T.M., Howlett A.C., Bonner T.I., Matsuda L.A., Herkenham M. Cannabinoid receptor binding and messenger RNA expression in human brain: an in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains // Neuroscience. 1994. Vol. 63. P. 637-652.
207. Won S.J., Kim D.Y., Gwag B.J. Cellular and molecular pathways of ischemic neuronal death // J Biochem Mol Biol. 2002. Vol. 35. Is. 1. P. 67-86.
208. Won H., Lee H.R., Gee H.Y., Mah W., Kim J.I., Lee J., Ha S., Chung C., Jung E.S., Cho Y.S., Park S.G., Lee J.S., Lee K., Kim D., Bae Y.C., Kaang B.K., Lee M.G., Kim E. Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function // Nature. 2012. Vol. 486. Is. 7402. P. 261- 265.
209. Xiang G., Pan L., Huang L., Yu Z., Cheng J., Xing W., ZhouY. Microelectrode array-based system for neuropharmacological applications with cortical neurons cultured in vitro // Biosens Bioelectron. 2007. V. 22(11). P. 2478- 2484.
210. Xiong Y., Mahmood A., Chopp M. Emerging treatments for traumatic brain injury // Expert Opin Emerg Drugs. 2009. Vol.14, №1ю Р.67-84.
211. Yamamoto M., Takahashi K., Ohyama M., Yamaguchi T., Saitoh S., Yatsugi S., Kogure K. Behavioral and histological changes after repeated brief cerebral ischemia by carotid artery occlusion in gerbils // Brain Res. 1993. Vol. 608, № 1. P. 16-20.
212. Younts TJ, Castillo PE. Endogenous cannabinoid signaling at inhibitory interneurons // Curr Opin Neurobiol. 2014. Vol. 26. P. 42-50.
213. Zakharov Y.N., Mitroshina E.V., Shirokova O.М., Mukhina I.V. Calcium transient imaging as tool for neuronal and glial network interaction study // Springer Proceedings in Mathematics and Statistics (Models, Algorithms, and Technologies for Network Analysis). 2013. Р. 225-232.
214. Zhang M, Martin BR, Adler MW, Razdan RK, Jallo JI, Tuma RF. Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model //J. Cereb. Blood. Flow. Metab. 2007. Vol.27. Р.1387-1396.
215. Zhang M., Martin B.R. et al. Modulation of The Balance Between Cannabinoid CB1 and CB2 Receptor Activation During Cerebral Ischemic/Reperfusion Injury // Neuroscience. 2008. Vol. 152, №3. 753-760.
216. Zhang M., Martin B.R. et al., Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke // J. Neuroimmune Pharmacol. 2009. Vol. 4, 32. Р. 249-259.
217. Zimmer A. et al. Increased mortality, hypoactivity and hypoalgesia in cannabinoid CB1 receptor knockout mice // Proc. Natl. Acad. Sci. 1996. Vol. 7. P. 5780-5785.
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