Given the presence of antimicrobial activity for tetrazole derivatives and its condensed analogues, it was proposed to analyze 13 novel 5-phenyl-5,6-dihydrotetrazolo[1,5- c]quinazolines for molecular docking to ribosomal in comparison with Tedizolid.

Structural formula of Tedizolid as antimicrobial and structural analogue and proposed 5-phenyl-5,6-dihydrotetrazolo[1,5-c]quinazolines. Affinity to binding sites of 2QEX, with decreasing of score. Descriptives of formed bonds to 50S ribosomal protein L2P.

Microscopic fungi including yeasts are important part of human microbiota. The molecular genetic identification of human sputum yeast isolate MF22_1, belonging to Candida spp., by using multiple genetic markers including ribosomal operon regions.

Issues of differential diagnostics, treatment of endometrial hyperplasia in women of reproductive age using various types of progestins. Study of the algorithm for predicting the effectiveness and review of the causes of resistance to progestin therapy.

Non-adjuvant polychemotherapy - technology that indicates the presence of chemo-resistant tumor cells. Molecular-biological markers of tumors - certain chromosomal and gene mutations that involved in the development, progression of malignant diseases.

A stable antibody which can be used over a period of time. Extract mouse tumour cells, which grow continuously, and culture them in the laboratory. Analizes of immune response to monoclonal antibodies produced in mice, as these are foreign proteins.

Study of the structure of neurons in the anterior horns of the spinal cord in PIPN with the introduction of 2-ethyl-6-methyl-3-hydroxypyridine succinate. Metabolic effect of correction of morphofunctional state of spinal cord motoneurons in white rats.

The types of morphological changes in the complete blood count, along with other laboratory parameters, can help establish the severity of the condition and provide the prognostic value in determining the survival of a sick patient with COVID-19.

Features of morphostructural changes in the uterus of rats with prevailing hemodynamics disorder of the organ in NNLA-injection. Microcirculatory changes as a manifestation of vascular decompensation, accompanied by disturbances of blood rheology, etc.

Combined impedance monitoring in patients with gastroesophageal reflux. Functional disorders of the esophagus in patients with proton pump inhibitor deficiency. Comparative characteristics of reflux between respondents and nonresponders receiving PPI.

Analysis of the medical and social problem of rheumatoid arthritis. The nature of the course of the disease, the main lesions of the musculoskeletal system. The effectiveness of exercise during the rehabilitation of patients with rheumatoid arthritis.

Tongue piercing and associated dental complications. The case presented here draws attention to the possibility of multiple tooth fracture as a result of trauma incurred from a barbell inserted into the tongue: systemic complications of this practice.

The specificity of multiple sclerosis lies in the young age of patients with various symptoms and unpredictability of the disease. Factors are the reason that rehabilitation of patients is one of the most difficult tasks of neurological rehabilitation.

Определение серотипов, генотипов и резистентности к антимикробным препаратам штаммов Streptococcus pneumoniae, полученных от здоровых детей и детей с различными формами пневмококковой инфекции. Пути преодоления резистентности в современных условиях.

Definition, the basic physical and chemical properties, advantages and possibilities of application of nano-emulsions in the pharmaceutical, cosmetic, food, chemical industries. Characteristics of the methods and mechanisms for obtaining nanoemulsions.

Bioavailability and increased shelf life of the pharmaceuticals - nanoemulsions. The ability of nanoemulsions to dissolve large quantities of hydrophobics, along with their ability to protect the drugs from hydrolysis and enzymatic degradation.

To study the prospects of using nanoemulsion in the modern pharmaceutical industry. Bioavailability of colloidal solutions. The ability of the solubility of nanoemulsions and their ability to protect drugs from hydrolysis and enzymatic degradation.

Various forms of the crystals formed during evaporation of biological liquids of women. Physical and chemical bases of salts polymorphism, process arborization. The cyclic change in electric potential in biological liquids during the menstrual cycle.

An urgent need to develop a system that helps doctors to diagnose dermatology in its early stages. Neural networks in building an intelligent system with 100% accuracy to identify some skin diseases. Applying the particle swarm optimization algorithm.

Investigate a possible role of the polymorphisms by comparing the distribution of genotypes in the control group and in patients with type two diabetes mellitus and retinopathy. Analysis of the reasons for the increase in the frequency of heterozygotes.

New patterns of the onset of gestational diabetes mellitus and the course of diabetes mellitus before pregnancy were revealed. The relationship of diabetes mellitus with the age of the pregnant woman and with the risk of preeclampsia is described.

Генетические факторы, вовлеченные в патогенез болезни Паркинсона. Анализ "нейродегенеративных панелей". Верификация отдельных вариантов с помощью секвенирования по Сенгеру. Использование современных технологий полногеномного ассоциативного анализа.

Adaptation to eugenol and citral by exposure of pathogens to increasing concentrations of essential oils. Determination of antibiotic susceptibility. Evaluation of the effect of eugenol and citral on the adherence ability by the crystal violet assay.

Роль NO-синтаз і ядерного фактора B (NF-B) у механізмах порушень білоксинтезуючої функції піднижньощелепних слинних залоз за умов моделювання метаболічного синдрому. Функціонування NO-синтази, пригнічення активності -амілази та орнітиндекарбоксилази.

Вплив циркулюючих імунних комплексів на ультраструктурні особливості клітин. Корекція функціонально-структурних порушень, зумовлених хронічною гіперімунокомплексемією, за допомогою корвітину. Синтез оксиду азоту у тканинах печінки та ендотеліоцитах.

Исследовались особенности осмотической резистентности тромбоцитов, подвергнутых преинкубации с донатором оксида азота (нитропруссидом натрия) в конечной концентрации. Оценивалось изменение количества свободных клеток и агрегатов, их размеров и формы.

Дослідження активності ензимів окисного шляху метаболізму L-аргініну в лімфоцитах периферичної крові хворих на реактивний артрит. Вивчення кінетичних властивостей NO-синтаз. Оптимальні умови функціонування ендотеліальної та індуцибельної NO-синтаз.

Apical periodontitis is a disease of root canal infection. The etiology of post-treatment apical periodontitis. Exogenous materials causing foreign body reaction at the periapex. Endogenous substances and foreign body reaction. Biology of cholesterol.

Pleural effusion is an abnormal accumulation of fluid between the visceral, parietal layers of the pleura. Chemical pleurodesis is an artificial induction of an aseptic inflammatory process by introducing various chemical agents into the pleural cavity.

Analysis of the study of colorectal motility in humans and disorders found in constipation with slow transit. The main characteristic of motor activity of the colon. Peculiarity of detecting specialized distributed activity with driving properties.