Комбіноване лікування хворих на рак передміхурової залози в стадії Т3 – Т4 з використанням малих доз естрогенів

Оцінка клінічної ефективності використання низьких доз естрогенів в поєднанні з хірургічною кастрацією в лікуванні хворих на рак простати. Розробка методів імунологічного контролю за перебігом і ефективністю лікування хворих на рак передміхурової залози.

Рубрика Медицина
Вид автореферат
Язык украинский
Дата добавления 26.09.2015
Размер файла 55,1 K

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The combined RPZ treatment, with application of castration,in combination with Sinestrole, in small doses - ensured the achievement of stable clinical effect in patients with RPZ, with ІІІ-ІI stage, end the 3 - year survival of patients with ІІІ-ІI stages of disease - made 88% and 63 % - correspondingly. The androcur application, in combination with castration, rendered less stable and prolonged action, the 3 - year survival with III-IV steges made 84,6% and 60%, correspondingly. The synestrole application in traditional dopes - led to a rapid positive effect, but the indexes of the mark of patients' condition - turned out to be rather low, because of anpearence of considerable amount /65,7 % / of complications on the side of heart - vessel system, the 3 - year survivalwith ІІІ-ІЇ stages - made 86,4 % and 53,8% correspondingly. In bilateral orchiectomy application- the 3 - year survival with III-IV stages of the disease made 79,2 and 50% correspondingly.

Analysed was the condition of immune and cytokine status, in T2 and T4 stages, in the pre - operation period, and in early postoperative period, after orchiektomy - in T3 - T4 stage, as a part of antitumour resistence.

In patients with T2 tumours, before operation - the investigator observed the disbalance of T-cell subpopulations of lymphocytes: the growth of killers /suppressors and decrease of CD4/ CD8 proportion with T3 - T4 tumours - there were more expressed the signs of disbalance of T-cell lymphocytes subpopulations: decrease of CD4 / CD8 proportion; lowering of content of T-helpers and of killers - suppressors; lovering of receptors expression - to IL - 2 decrease of the Immunocytes number, with the HLA-Dr receptors expression.

In the early postoperative period, observed was the disbalance of T-cell lymphocytes subpopulations: decrease of CD4 / CD 8 proportion, the increase of the number of CD8 killers - suppressors, decrease of relative NK - cells number, with the HLA-Dr receptors expression.

The cytorine status: before operation: growth of anti - tumor cytorine - Interferon and decrease of the number of antitumor cutokin IL - 10; The lowering of antstumor IL - 2 and - FNP cytorine concentration. In the early postoperative period the immune response is initiated according to cell - type - incjnsiderable increase of antitumor - Interferon concentration, and decrease of antittumor IL - 10 cytorine, increase of antitumor cytorine IL- 2 and - FNP concentration.

Key words: PGC - prostate gland cancer, estrogens, bilateral orhiektomy, immune status, cytokines, cell immunity.

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