Клініко-патофізіологічні особливості перебігу вазомоторного риніту при тривалому застосуванні назальних деконгестантів

Аналіз стану вегетативної нервової системи у хворих на вазомоторний риніт, що тривало використовують назальні деконгестанти. Визначення стану їх місцевого імунітету та кровообігу. Оцінка ефективності відомих методів лікування хворих на вазомоторний риніт.

Рубрика Медицина
Вид автореферат
Язык украинский
Дата добавления 06.07.2014
Размер файла 43,1 K

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The dissertation for a scientific degree of the candidate of medical sciences in speciality 14.01.19 - otorhinolarygology. Institute of otolaryngology by prof. O.S.Kolomijchenko of Academy of medical sciences of Ukraine, Kiev, 2003.

The dissertation is devoted to questions of peculiarities, diagnostics, treatment of a vasomotor rhinitis (VR) at prolonged application of nasal decongestants (ND) and prophylaxis of medicamental dependence to them. 121 patients with VR at prolonged application of ND were investigated. It was revealed that risk factors of medicamental dependence to ND are the initial disturbances of a vegetative nervous system (VNS) state as prevalence of parasympathic part activity. They along make a basis for the development of medicamental dependence with rebound swelling. The constant application ND causes dynamic changes VNS activities resulting from boosting influence of ND on sympathetic part. As a result during the first year of ND use the normalization of VNS parameters is detected. ND application for more than one year causes activity predominance of sympathic part of VNS.

The prolonged application of ND leads to the disorders of the basic protective mechanisms of nasal mucosa and depression of vessel tone of nasal mucosa with the subsequent histic energy deficit. It results in series of disturbances of mucosa structural functional state. The constant application of ND in patients with VR causes an inhibition of local humoral immunity and activization of local cell immunity.

Surgical treatment in patients with VR at prolonged application of ND does not exclude an opportunity of relapse of the disease in the remoted term (20 % of causes) first of all because of conservation of risk factors of medicamental dependence. An inefficiency of medical measures and probability of relapse of the disease and medicamental dependence to ND using the treatment considering the vegetative disturbances (30,7-36,2 % of cases during 12 months of observations) are directly proportional to increase of terms of previous application of ND, that is connected with inhibition of sensitivity of adrenoreceptors at ND use for more than 1 year.

Key words: diagnostics, immunology, morphology, nasal decongestants, prophylaxis, rhinitis medicamentosa, treatment, vasomotor rhinitis, vegetative nervous system.

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