Патогенетичне обґрунтування фармакокорекції гіпоксичного синдрому похідними ксантину

Експериментальне обґрунтування доцільності профілактичного застосування препаратів з групи похідних ксантину при гіпоксичному синдромі. Визначення оптимальної дози застосування алкілксантину в умовах впливу на організм гострої гіпоксії на тлі гіпертермії.

Рубрика Медицина
Вид автореферат
Язык украинский
Дата добавления 07.01.2014
Размер файла 50,8 K

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Ключові слова: гіпоксія, гіпертермія, фармакокорекція, пентоксифілін.

Belousova I. P. The pathogenetical substantiation of pharmacocorrection of hypoxic syndrome by xanthine derivatives. - Manuscript.

Thesis on competition of a scientific degree of the candidate of medical sciences on a speciality 14.03.05 - pharmacology. - State medical university of Odessa. - Odessa, 2000.

The thesis is devoted to the pathogenetical substantiation of pharmacocorrection of HS, formed in conditions of an influence on an organism acute hypoxic hypoxia and hyperthermia by xanthine derivatives.

Is established, that the highest pharmacoprophylactic efficiency for want of given pathological condition among all investigated xanthine derivatives exhibits pentoxifylline for want of it enteralic introduction by an experimental animal in a doze of 150 mg/kgs 1 hour prior to effect of the extreme factors, for want of the average therapeutical doze of a preparation has made 120 mg/kgs.

Is shown, that in the basis of an antihypoxic operation of a preparation the ability it to prevent activation of processes of peroxidizing oxidation phospholipids membrane lies. That is exhibited in decrease of the contents of primary, intermediate and final products lipidperoxidation. The important role in realization by a preparation of an antihypoxic operation is played it by antiradical properties confirmed by a method BCL.

Significant influence to formation and the current of HS renders pentoxifyllines ability to prevent violation of antioxidanting-prooxidanting balance at the expense of preservation of activity of such components of the antioxidanting protective system of an organism, as catalase, SOD, glutatione, and prevention of decrease of the contents of the functional active SH-groups, and also to provide a sufficient level of protection of an organism from effect of the extreme factors owing of membrane stabilizer operation estimated on peroxidizing stability of erythrocytes membranes.

Key words: hypoxia, hyperthermia, pharmacocorrection, pentoxifylline.

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