Обґрунтування диференційованого лікування бронхіальної астми у дітей залежно від типу запалення дихальних шляхів

Аналіз моделі еозинофільного та нейтрофільного типу бронхіальної астми у школярів на підставі комплексної оцінки особливостей перебігу захворювання. Зміст стану імунологічних показників крові, гістохімічних маркерів гранулоцитів та дихального секрету.

Рубрика Медицина
Вид автореферат
Язык украинский
Дата добавления 26.08.2015
Размер файла 62,6 K

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Ortemenka Ye.P. Substantiation for differentiated treatment of bronchial asthma in children depending on the type of inflammation of airways. Manuscript.

Thesis for the obtaining the scientific degree of candidate of medical science in speciality 14.01.10 - Pediatrics. - Odessa State Medical University of the Ministry of Health of Ukraine. - Odessa, 2009.

The evaluation of bronchial asthma in school age children with different types of inflammation of airways has been performed on the base of the analysis of atopy markers, indices of non-specific reactivity of the bronchi to histamine inhalation and tolerance to physical activity together with immunological blood indices and histochemical granulocyte markers of sputum and blood, thus leading to identification of the characteristic features of both eosinophilic and neutrophilic types of disease .

Evidences have been given for the fact that clinical presentations of bronchial asthma as well as immunological and histochemical indices of the peripheral blood, atopy markers and non-specific hyperresponsiveness of bronchi are of different diagnostic and prognostic value for detection of eosinophilic and neutrophilic types of inflammation of airways in school age children. Differentiated risk factors of realization of eosinophilic and neutrophilic bronchial asthma in children have been defined based on the results of complex examination.

Mathematic model of eosinophilic and neutrophilic bronchial asthma has been created to provide correction for anti-relapsing basic therapy of the disease considering the type of inflammation respond of the airways. In terms of clinical epidemiology, the evaluation has been made of the efficiency of treatment by using various groups of medicines depending on the types of inflammatory respond of bronchi in school age children.

Innovation methods for both diagnostics and treatment have been developed and implemented, such as diagnostic table suitable for detection of either eosinophilic or neutrophilic type of disease in school age children and algorithm for the choice of differentiated treatment depending on the type of inflammation of airways. The efficiency of the offered methods has been proved in terms of clinical epidemiology.

Key words: bronchial asthma, children, types of inflammation, diagnostics, anti-inflammatory treatment.

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