Phenyhidin causes no intrinsic changes in the indices of the central and cerebral hemodynamics in ischemic insult patients. In 67 per cent of intracerebral hematoma patients the preparation reduces an average dynamic pressure because of its marked negative inotropic efficacy. Under phenyhidin effect autoregulating cerebral mechanisms tend to limit the blood flow to the brain despite the character of insult.

Diltiazem reliably descends an average arterial pressure regardless of character of insult. Its hypotensive effct is significantly more protracted in intracranial hematoma. The drug sufficiently ascends blood flow resistance in the precranial portion of the carotid arteries in ischemic insult patients, however, it having no marked influence on the blood flow in the cerebral vessels.

Nimodipin considerably decreases an average dynamic arterial pressure in hemorrhagic insult and results in rice the carotid vessels resistance, but essentially only common carotid arteries resistance, to hematomic mass grouth, promotes preventing blood supply in an increased intracranial pressure. Nimodipin negatively influences the cerebral blood flow in ischemic insult patients. The preparation increases circulatory resistance and descends linear blood flow velocity in the cerebral arteries. Nimodipin causes no intrinsic changes in the indices of the central hemodynamics. Nimodipin in combined treatig intracerebral hematoma patients reliably promotes improving the results of treatment at the end of a severe stage as compared to the similary cured patients but without applying the aforcited preparation.

Some practical recommendations were elaborated. It is safe to use diltiazem as a neuroprotective means in ischemic and hemorrhagic insults in arterial hypertension patients.

Phenyhidin as a neuroprotective means needs no sufficient correction of the central and cerebral hemodynamics. However, in hemorrhagic insults it is not worth to administrer phenyhidin in cases of negative inotropic efficacy of the remedy.

Nimodipin is worth to be prescribed to the intracerebral hematoma patients with (or without) blood discharge into the ventricls of the brain and subarachnoid space, it surving as a neuroprotective remedy and a preventive cerebral ischemia means without additional correction of the central and cerebral hemodynamics.

It is not expediant for ischemic patients to take nimodipin as a neuroprotector or an anti- ischemic remedy. In cerbral infarction it is safe to use some other calcium antagonists, diltiazem or phenyhidin, namely.

Key words: ischemic insult, hemorrhagic insult, calcium antagonists, phenyhidin, dilthiazem, nimodipin, cerebral hemodynamic, central hemodynamic.

Перелік умовних скорочень

ВМГ внутрiшньомозкова гематома

ВСА(С) внутрiшня сонна артерiя (супраклиноїдна порцiя)

ВЧТ внутрiшньочерепний тиск

ГІ геморагiчний iнсульт

ГП гостра проба

ЗСА загальна сонна артерiя

ЗПСО загальний периферичний судинний опiр

ІІ iшемiчний iнсульт

ЛШК лiнiйна швидкiсть кровотоку

НБА надблокова артерiя

РБТ робота серця

САТ середньодинамiчний артерiальний тиск

СІ серцевий iндекс

СМА середня мозкова артерiя

УІ ударний iндекс

УО ударний об'єм

ХО хвилинний об'єм

ЧСС частота серцевих скорочень

FD (VD) дiастолiчна частота (дiастолiчна швидкiсть)

FM (VM) мiнiмальна частота (мiнiмальна швидкiсть)

FS (VS) систолiчна частота (систолiчна швидкiсть)

PI пульсацiйний iндекс

RI iндекс резистентностi

SD систолiчно-дiастолiчний iндекс (спiввiдношення)

TAM середня частота (швидкiсть)

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