Изучение молекулярных основ предрасположенности к раку желудка

13. Sun L., Sun Y.H., Wang B., Cao H.Y., Yu C.: “Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis”. Eur J Cancer Prev., 2008; 17: 446- 452.

14. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol. Microbiol. Scand. 64:31-49, 1965.

15. Hamilton, J.P., Meltzer, S.J. “A review of the genomics of gastric cancer”. Clin. Gastroenterol. Hepatol. 2006, 4: 416-425.

16. Lei G., Alexandra N., Hermann B. “Cell proliferation-related genetic polymorphisms and gastric cancer risk: systematic review and meta-analysis”. E. J. Human Genetics, 2009, 17, 1658 - 1667.

17. Nau M. Brooks B.J., Battey J., Sausville E., Gazdar A.F., Kirsch I.R., et al. “L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer”.Nature 1985; 318:69-73.

18. Kaye F., Battey J., Nau M., Brooks B., Seifter E., De Greve J., et al. “Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing. Mol. Cell Biol.1988; 8:186-195.

19. Ge H., Lam W.K., Lee J., Wong M.P., Yew W.W., Lung M.L. “Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients. Lung Cancer 1996; 15:355-366.

20. Shibuta K., Mori M., Haraguchi M., Yoshikawa K., Ueo H., Akiyoshi T. “Association between restriction fragment length polymorphism of the L-myc gene and susceptibility to gastric cancer. Br J Surgery 1998; 85:681-684.

21. Spinola M., Nomoto T., Manenti G., Falvella S., Brega Massone P.P., Conti B., et al. “Linkage disequilibrium pattern in the L-myc gene in Italian and Japanese non-small-cell lung-cancer patients”. Int. Cancer, 2001; 95:329--331.

22. Кнорре Д. Г., Мызина С. Д. Биологическая химия. -- 3. -- Москва: Высшая школа, 2000. -- 479 с., Глик Б., Пастернак Дж. Молекулярная биотехнология. Принципы и применение. -- Москва: Мир, 2002. 589 с.

23. Dlugosz A., Adler G., Ciechanowicz A., Jaroszewicz-Heigelmann H., Starzynskaa T. “EcoRI polymorphism of the L-myc gene in gastric cancer patients”. E. J. Gastr.Hep. 2002, 14:1231-1235

24. Kakehi, Y., and Yoshida, O. “Restriction fragment length polymorphism of the MYCL1 gene and susceptibility to metastasis in renal cancer patients”. Int.J. Cancer, 1989, 43, 391-394.

25. Kato M., Toguchida J., Honda K., Sasaki M.S., Ikenaga M., Sugimoto M., Yamaguchi T., Kotoura Y., Yamamuro T., Ishizaki K. “Elevated frequency of a specific allele of the MYCL1 gene in male patients with bone and soft-tissue sarcomas”. Int. J. Cancer, 1990, 45, 47-49.

26. Taylor J.A., Bell D.A., Nagorney D. “MYCL1 protooncogene alleles and susceptibility to hepatocellular carcinoma”. Int. J. Cancer, 1993, 54, 927-930.

27. Shibuta K., Inoue H., Sato K., Matsuyama A.., Ueo H., Tanaka Y., Mafune K., Barnard G.F., Mori M. “MYCL1 restriction fragment length polymorphism in Japanese patients with esophageal cancer”. Jpn. J. Cancer Res., 2000, 91, 199-203.

28. Ishizaki K., Kato M., Ikenaga M., Honda K., Ozawa K., Toguchida J. “Correlation of MYCL1 genotypes to metastasis of gastric cancer and breast cancer”. J. Natl Cancer Inst., 1990, 82, 238-239.

29. Mironov N.M., Aguelon A.M., Potapova G.I., Gorbunov O.V., Klimenkov A.A., Yamasaki H. “MYCL1 allele polymorphism and prognosis for metastases in Russian gastric cancer patients”. Eur J Cancer, 1994, 30A, 1732.

30. Onda M., Matsukura N., Matsukura N., Tokunaga A., Matsuda N., Yamashita K., Shields P.G. “Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study”. Cancer 77, Suppl 8, 1996, 1654-1661.

31. Isbir T., Yaylim I., Arikan S., Kaytan E., Karsidag T., Bayrak S., Camlica H. “Close correlation between restriction fragment length polymorphism of MYCL1 gene and susceptibility to gastric cancer”. Cancer Detect Prev 6, 2002, 454-457.

32. Knoepfler P.S., Zhang X.Y., Cheng P.F., Gafken P.R., McMahon S.B., Eisenman R.N. “Myc influences global chromatin structure”. EMBO J. 25, 2006, 2723-2734.

33. Eilers, M., Eisenman R.N. “Myc's broad reach”. Genes Dev., 2008, 22, 2755-2766.

34. Spinola M., Falvella F.S., Galvan A., Pignatiello C., Leoni V.P., Pastorino U., Paroni R., Chen S., Skaug V., Haugen A., Dragani T.A. “Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung

cancer patients' survival”. Lung Cancer, 2007, 55, 271-277.

35. Ikeda I., Ishizaka Y., Ochiai M., Sakai R., Itabashi M., Onda M., Sugimura T., Nagao M. “No correlation between MYCL1 restriction fragment length polymorphism and malignancy of human colorectal cancers”. Jpn. J. Cancer Res., 1988, 79, 674-676.

36. Kawashima K., Nomura S., Hirai H., Fukushi S., Karube T., Takeuchi K., Naruke T., Nishimura S. “Correlation of MYCL1 RFLP with metastasis, prognosis and multiple cancer in lung-cancer patients”. Int. J. Cancer, 1992, 50, 557-561.

37. Ge H., Lam W.K., Lee J., Wong M.P., Yew W.W., Lung M.L. “Analysis of MYCL1 and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients”. Lung Cancer, 1996, 15, 355-366.

38. Presti J.C., Hinckley J., Reuter V.E. “MYCL1 allelotype in renal cell carcinoma”. Cancer Genet. Cytogenet., 1996, 88, 66-68.

39. Spinola M., Pedotti P., Dragani T.A., Taioli E. Meta-analysis suggests association of MYCL1 EcoRI polymorphism with cancer prognosis. Clin Cancer Res 2004, 10, 4769-4775.

40. Schwab M., Alitalo K., Klempnauer K.H., Varmus H.E., Bishop J.M., Gilbert F., Brodeur G., Goldstein M., Trent J. “Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour”. Nature,1983, 305, 245-248.

41. Bishop J.M. “The molecular genetics of cancer (review)”. Science, 1987, 235, 305-311.

42. Chen Sh., Lin X., Zhu J., Tang Y., Lin J. Association of a MYCL1 Single Nucleotide Polymorphism, rs3134613, with Susceptibility to Diffuse-Type Gastric Cancer and with Differentiation of Gastric Cancer in a Southeast Chinese Population. DNA CELL BIO., Vol. 29, Number 12, 2010, 739-743.

43. Hanahan D., Weinberg R.A. “The hallmarks of cancer (review)”. Cell, 2000, 100, 57-70.

44. Weston A., Ling-Cawley H.M., Caporaso N.E., Bowman E.D., Hoover R.N., Trump B.F., et al. “Determination of the allelic frequencies of an L-myc and p53 polymorphism in human lung cancer”. Carcinogenesis, 1994; 15:583-587.

45. Crossen PE, Morrison MJ, Colls BM. Increased frequency of the S allele of L-myc oncogene in non-Hodgkin's lymphoma. Br. J. Cancer, 1994; 69: 759-761.

46. Young J, Buttenshaw R, Butterworth L, Ward M, Searle J, Leggett B, et al. Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers. Oncogene, 1994; 9:1053-1056.

47. Goracy I., Goracy J., Suliga M., Ciechanowicz A. “C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in patients with myocardial infarction”. Pol. Arch. Med. Wewn., 1999; 4:849-854.

48. С. С. Харнас, В. В. Левкин, Г. Х. Мусаев. Рак желудка: клиника, диагностика, лечение

49. [www.eurolab.ua]

50. Щепотин И.Б., Эванс С.Р. Рак желудка: практическое руководство по профилактике, диагностике и лечению. Киев «Книга Плюс» 2000.-227с.

51. М.С.Абдуллаходжаева «Основы патологии человека» часть 2 Ташкент 1997г.

52. DePinho R.A., Schreiber-Agus N., Alt F.W. myc family oncogenes in the development of normal and neoplastic cells // Adv.Cancer Res. 1991. V. 57. P. 1--46.

53. Dang C.V. c-Myc target genes involved in cell growth, apoptosis, and metabolism // Mol. Cell Biol. 1999. V. 19. P. 1--11

54. Iversen P.L., Arora V., Acker A.J., et al. Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans // Clin. Cancer Res. 2003. V. 9. P. 2510--2519

55. Soucek L., Helmer-Citterich M., Sacco A., et al. Design and properties of a Myc derivative that efficiently homodimerizes // Oncogene. 1998. V. 17. P. 2463--2472

56. Корнбсрг А., Синтез ДНК, пер. с англ., М., 1977, с. 298-305; Баев А. А., Таняшин В.И., Федор И., в сб.: Итоги науки и техники, сер. Молекулярная биология, т. 12, ч. 1. Генетическая инженерия, М., 1979; Kessler Оh, Neumaier P.S, Wolf W., "Gene", 1985, v. 33, № 1, p. 1-102.

57. Askers G.K. Steere R.L. (1962) Restricted diffusion macromolecules through agar-gel membranes. Biochim. Biophys. Acta, 59(1), 137-149

58. Kakehi и Yoshida, 1989; Kato и др., 1990; Taylor и др., 1993; Shibuta и др., 2000; Spinola и др., 2001.

59. Ishizaki и др., 1990; Mironov и др., 1994; Onda и др., 1996; Shibuta и др., 1998; Dlugosz и др., 2002; Isbir и др., 2002.

60. Ikeda и др., 1988; Kawashima и др., 1992; Ge и др., 1996; Presti и др., 1996; Spinola и др., 2004

61. Schwab и др., 1983; Bishop, 1987; Hanahan и Weinberg, 2000

ПРИЛОЖЕНИЕ

Нуклеотидная последовательность гена L-myc

cgggccgcatcagccctcctcctgtttgcgctccccagcgtgcaatttatttggggggctaccggggattgaacggagcgggcgagcgctgccaggaggtggggccggccccacctgtcgactgcccgtagtaggcagggagagggcggggtttgtcccatagggcccgccccccagtccctgggtcccgggcgcgcgacgagatataaggcagtcaggaaacaatgcgcctgcagctcgcgctcccgcgccgatcccgagagcgtccgggccgccgtgcgcgagcgagggagggcgcgcgcgcggggggggcgcgctcgtgagtgcgggccgcgctctcggcggcgcgcatgtgcgtgtgtgctggctgccgggctgccccgagccggcggggagccggtccgctccaggtggcgggcggctggagcgaggtgaggctgcgggtggccagggcacgggcgcgggtcccgcggtgcgggctggctgcaggctgccttctgggcacggcgcgcccccgcccggccccgccgggccctgggagctgcgctccgggcggcgctggcaaagtttgctttgaactcgctgcccacagtcgggtccgcgcgctgcgattggcttcccctaccactctgacccggggcccggcttcccgggacgcgaggactgggcgcaggctgcaagctggtggggttggggaggaacgagagcccggcagccgactgtgccgagggacccggggacacctccttcgcccggccggcacccggtcagcacgtccccccttccctcccgcagggagcggacatggactacgactcgtaccagcactatttctacgactatgactgcggggaggatttctaccgctccacggcgcccagcgaggacatctggaagaaattcgagctggtgccatcgccccccacgtcgccgccctggggcttgggtcccggcgcaggggacccggcccccgggattggtcccccggagccgtggcccggagggtgcaccggagacgaagcggaatcccggggccactcgaaaggctggggcaggaactacgcctccatcatacgccgtgactgcatgtggagcggcttctcggcccgggaacggctggagagagctgtgagcgaccggctcgctcctggcgcgccccgggggaacccgcccaaggcgtccgccgccccggactgcactcccagcctcgaagccggcaacccggcgcccgccgccccctgtccgctgggcgaacccaagacccaggcctgctccgggtccgagagcccaagcgactcgggtaaggacctccccgagccatccaagagggggccaccccatgggtggccaaagctctgcccctgcctgaggtcaggcattggctcttctcaagctcttgggccatctccgcctctctttggctgaagctgcccgtgtagtccccaaccgtgtctgtctggcacgtgggtgtgttggtaaacagtttggaaaagtggcgtgggagccagcctccctttgatgattattggagccccaggggacaagggatttgaggtgagggttggcgcttagagaggacaatactggggttggactgtaagggattgaagggggtaccttaagagacactccaaacctgaagtttttttgctgctgcctctttccctaggaaactcacactcccctagggggagaagaagccgagagccttttgtgcaaagccaaaaccttcgtccttttaaaaacctaggtctccagttggctttactttaaaatgccaataataaatgccctcttctcgtgcctccccaccaccacttaccactcgtgcatccctgagacagggagggaagaatgaacactccccattaacagatggaaaaactgaggcttagagatagacaatcactacaagtcagctccagctttctgccatctagccagcccctcttccccaatgctccatcccaaccaggcacctcttccttgatgtttggggtctttgtggtagcttatcttagaagcactacaccttgccttgctgtttgtcctgagatggaaaagtgtccttcttgctccccctcaatagatctccagcgtcagctgctccctggcattcaacaaatattcactggcccctactttgtggcaatctgtgggctacatgctggggtcaaggcagtagaactccaggccctcctctcccatccttgatgcaagtgcaacctcgctgagggcagactggggcatcctgtgccactaaactacattgttcttattctggcatcttagacctccacacccgtgagaaatcctggagagggtatttttgtagagtgtagactgtggctagtgacaaataaattaggaccaagaaagctcactgtagcttttaggaataacttttacacgaccatttgatagggaactggggaatggggtatggaagttttcctacacttgagagaaaaaataggataacaaaaattaaaagtctttttttcctggtccactgtgttaaggtcatttttaaccagcttgctttctacaccaagagtttatgtttgtttaatggctggaaagagaatcttgagatcaaaaaaccaataaagatgtatctctacaacggctggtggagtggtagagtggaaagagcattgctttggaagttggaacattttagtttgagatccagaacgttacaaaggtgatatgtggacttcgctgatctgggcctcagtttccccatttgcacacgatggggttggacttgattgtcctgctgatgacatttccttgtctggatagagtaagacactactctctgaaagggagaatggtgtgcttaaattatttctttcttagatagaatcttcctgagccacgaggcttaacactgaaaattaaaggtttgggatgtaggaaagcctgctgaatcattttctaacctaccctttaacctgaacctgtttgtgagcttctagttcactcacaggccacatggcctggaacaaaatgcaacagattgcaaacaatgaggcggggggtggggaaagtgattggcagcagagctcacccaataggggctaggggctgggtaagacagaattccaaacacagcgtaatcagccaatcatgggctttggggccaggagggctgaatggtcaggtttattaatggagaaataatgcgattgtccacacaatggaagccttcctgacaaaggggctcaagcttcctgatatgcaaagaagctgagaacggagctcttcctttgccgaggccgagatccattaaggtcggacttctgtgtggaggctgcaaaatgtgtggagcaggaggagacttttctcccaattgcccctctcctggttaggttaacctaagagaccttcaagccagtgaatgagaagggcgtgtccaggtgtctccaggtctctggtgttatgagccccatatctgggacattctgctgcccagtctctgcctctggtgcaggtagtttggaaatggtcgcttgtacctttgtgaagttcctgcagcttcgccgacctatgattacaaatctaaccttctagtccagggaaggaggtggggcaggcgacctataaatgatggatgactttagaaacccattgaacccaggagcaaaatgctcctaagggaaaccctttccctcccctctgtgggtgaagagggatgggttgtagccctcccttctctgaatcttcagctgaaagggatggcagaatagagaggtgggggaataataggatttataacttgtgaaaagtaacaattccccaagtgcaggctgtgctgggcaggaacaaagggcagctctgcccacagacccctcatttacaattctgatggggcatgaaagagcccgactggggaagatctttatagctaaactttgtcccaggccggtagctctttctctccaacccctccgtgggggaggggagagcctttgcagactgggggctgttggcttgggtctgccttttgttcttatctaagccttgctgtgcaaaaggaaattggagaatattttccttcttgctaatgtcccctcctttccttcactgtgcccttaccacattacaaatgaatcagctttctgctcacctcgatttgtatatatctaaattggaaaaatgtctcctaccttcccaagcaccagcgtagacagctaaagctgtagggtctatgtttgtgtttctcatgggatgtgtttcttctcttgatctcttttctcggacagagaatgaagaaattgatgttgtgacagtagagaagaggcagtctctgggtattcggaagccggtcaccatcacggtgcgagcagaccccctggatccctgcatgaagcatttccacatctccatccatcagcaacagcacaactatgctgcccgttttcctccagaaagctgctcccaagaagaggcttcagagaggggtccccaagaagaggttctggagagagatgctgcaggggaaaaggaagatgaggaggatgaagagattgtgagtcccccacctgtagaaagtgaggctgcccagtcctgccaccccaaacctgtcagttctgatactgaggatgtgaccaagaggaagaatcacaacttcctggagcgcaagaggcggaatgacctgcgttcgcgattcttggcgctgagggaccaggtgcccaccctggccagctgctccaaggcccccaaagtagtgatcctaagcaaggccttggaatacttgcaagccctggtgggggctgagaagaggatggctacagagaaaagacagctccgatgccggcagcagcagttgcagaaaagaattgcatacctcagtggctactaactgaccaaaaagcctgacagttctgtcttacgaagacacaagtttattttttaacctccctctcccctttagtaatttgcacattttggttatggtgggacagtctggacagtagatcccagaatgcatt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